Improving energy - mitochondrial, adrenal and thyroid support
Fatigue is the symptom we experience when energy demand exceeds energy delivery so attention to both sides of the equation is needed. In thinking about energy delivery a useful analogy is to think of the body as a car:
Mitochondria are the miniscule engines that burn fuel (acetate groups from fat and sugar) in the presence of oxygen to provide energy for every living cell in the body. We have published three studies showing that mitochondria running slowly is the central cause of fatigue in CFS/ME. Mitochondria go slow for two common reasons - either they are deficient in micronutrients so the enzymes do not work well, or they are blocked by toxins. The third paper we published showed that the nutritional deficiencies are corrected reliably well with all or a combination of micronutrient supplements and this is paralleled by clinical and biochemical improvement.
A typical regime, if the gut works perfectly, would include magnesium 300mgs by mouth (but ideally magnesium by injection), co enzyme Q 10 200mgs, acetyl L carnitine 2 grams, D-ribose 15 gms, niacinamide 1500 mgs and vitamin B12 1mg by mouth (ideally by injection). These should be taken in addition to the Basic Package and, where tests indicate, extra anti-oxidants.
If gut function is impaired by allergy and/or fermenting gut then injections become more important (only available on prescription). If injections are not available then transdermal nutrients may be helpful.